After years of repeated denials, Lance Armstrong is finally coming clean.
In a pre-taped interview with Oprah Winfrey, the seven-time Tour de France winner reportedly admitted to using performance-enhancing drugs.
And who better to open up to than the queen of talk TV? Over the years, plenty of stars have turned to Winfrey, whether they wanted to confess, apologize or just get something off their chest.
READ: Lance Armstrong and Seven Celebs Who Lost Their Endorsement Deals
Winfrey is also calling the sit-down "the biggest interview of my career," but it's certainly not the first time a guest of hers has made headlines.
Before the pre-taped show airs Thursday at 9 p.m. ET on the OWN network, let's have a look back at who else landed in the news after chatting with Oprah.
In what became one of the most watched interviews in American television history, the King of Pop’s sit-down with Winfrey made headlines when he admitted to having a nose job. At the time of the 1993 interview, Jackson’s appearance had many Americans questioning whether he had gone under the knife.
Cruise and the famous couch jump. "I'm in love! I'm in love!" he proclaimed of then-girlfriend Katie Holmes. The couple divorced after five years.
In 2009, Houston told Winfrey that she was, at times, a heavy user of drugs including marijuana and cocaine. "Don't think I don't have desires for it," she said, adding that when she feels like using, she has to "pray it away."
Following allegations that her then-husband and presidential candidate John Edwards fathered a child with a campaign videographer, Winfrey asked Elizabeth if she still loved her husband. Her response: "You know, that's a complicated question," made headlines in 2009.
The singer raised a few eyebrows in 2012 when she admitted during her chat with Winfrey that she was "still in love" with notorious ex Chris Brown. "We've built a trust again. We love each other and we probably always will," she added.
After being left off the invite list to Prince William and Kate Middleton's royal wedding, the Duchess of York revealed that being snubbed was "difficult," as she had hoped to attend with her daughters, who made the cut. "The last bride up that aisle was me," she added.